Cast[]
- Derek Theler as Erik Stephan Josten / Atlas / Wolverine
- Florence Pugh as Galina Anokhin / White Recluse
- Violet McGraw as Young Galina Anokhin
- Sebastian Stan as James Buchanan Barnes / Revolution
- Wyatt Russell as Adam Walker / American Agent
- Hannah John-Kamen as Ava Starr / Fantasma
- Olga Kurylenko as Marina Egorav / Recluse
- Lewis Pullman as William "Billy" Turner / Sentry / Void
- Geraldine Viswanathan as Belinda Thompkins / Black Goliath
- Alexa Swinton as Anya Petrova / Orphan Maker (flashback & illusion)
- Rachel Weisz as Melina Vostokoff / Iron Maiden (post-credit scene)
- Jessica Belkin as Tandy Bowen / Dagger (post-credit scene)
- Georges St-Pierre as Fredric Woolrich / Heat-Ray (deleted scene)
- Ayo Edebiri as Veronica Dultry / Dragonfly (deleted scene)
- Tim Blake Nelson as Burton Horowitz / Omnibus (deleted scene)
- Jeremy Renner as Clinton Francis Barton / Hawkeye (footage)
- Tom Holland as Peter Benjamin Parker / Spider-man (footage)
- Scarlett Johansson as Natalia Alianovna Romanova / Black Widow (flashback)
- Emma Roberts as Melinda "Lindy" Lee Jensen-Reynolds
- Rachele Schank as Victoria Louise Hand
- Margaret Qualley as Doctor Karlin Malus
- Wendell Pierce as Congressman Terrance "Terry" Jensen
- Gabrielle Byndloss as Andrea Sterman
- Simu Liu as Shang-Chi Zheng (post-credit scene)
- Jodie Turner-Smith as
- as Tyrone Johnson / Cloak
- as Calvin Montgomery "Cal" Rankin / Mimic
- as Michael Pointer / Weapon Omega
- as Emma Grace Frost / White Queen
- as Robert Herman / Glob Herman
- as Benjamin Hammil / Match
- as Dominikos Ioannis Petrakis / Avalanche
- as Sidney Green / Onyxx
- as Victor Borkowski / Anole
- as Alison Blaire / Dazzler
- as Eric Gitter / Ink
- as Jean-Paul Beaubier / Northstar
- as Kurt Szardos / Nightcrawler
- as Adam Neramani / Adam-X
- as Scott Summers / Cyclops
- as Henry Philip McCoy / Beast
- as Jeremiah Muldoon / Meld
- as Julian Keller / Hellion
- as Roberto Da Costa / Sunspot
- as Lorelei Travis
- as Akihiro
- as Shannon Queller
- as Simon Trask
- as Namor McKenzie
Other Cast[]
- Élodie Yung as Elektra Natchios
- Blake Lively as Karla Sofen / Moonstone
- Mike Colter as Lucas Cage / Power Man
- Boyd Holbrook as Charles Bernard Barton / Trickshot
- Alaqua Cox as Maya Wingfoot / Echo
- Rachael Taylor as Patricia Walker / Hellcat
- Tim Roth as Emil Blonsky / Abomination
- Paul Bettany as Victor Shade / Vision
- Jon Bernthal as Francis Grimm Castle / Punisher
- Jane Kim as Alessa Geomi / Bride of Nine Spiders
- Justin Chon as Chen Lu / Radioactive Man
- Steven Yeun as Chen Lu / Radioactive Man / Mister Negative / Sentry / Amedeus Cho / Tae-Won
- Liu Yifei as Seol Hee / Luna Snow
- Alice Eve as Mary Alice Walker / Typhoid Mary
- Ella Purnell as Melissa Joan Gold / Songbird
- Sadie Sink as Melissa Joan Gold / Songbird
- Ryan Gosling as Johnathon Blaze / Ghost Rider / Sentry
- Emily VanCamp as Sharon Carter / Agent 13
- Letitia Wright as Shuri Udaku / Aja-Adanna
- Ryan Reynolds as Wade Winston Wilson / Deadpool
- Tatiana Maslany as Jennifer Susan Walters / She-Hulk
- Harrison Ford as Robert Leslie Maverick / Red Hulk
- Oscar Isaac as Marcus "Marc" Spector / Moon Knight
- Hailee Steinfeld as Katherine Elizabeth Bishop / Lady Hawkeye
- Anthony Mackie as Samuel Thomas Wilson / Captain Falcon
- Krysten Ritter as Jessica Campbell Jones / Jewel
- Jameela Jamil as Sharon Ventura / Giganta
- Liv Tyler as Elizabeth Ross / Red She-Hulk
- Erik LaRay Harvey as Willis Stryker / Diamondback
- Hayley Atwell as Margaret "Peggy" Alexandra Carter / Agent Dryad
- Paul Rudd as Scott Wright / Micromax
- Chris Evans as Steven Grant Rogers / Captain America
- Robert Downey Jr. as Victor Werner von Doom / Doctor Doom
- Nathalie Emmanuel as Sonya Van Jagt / Saint Hildegard
- Justin Kucsulain as Robert "Bob" Reynolds / Sentry
- Julia Louis-Dreyfus as Valentina Allegra de Fontaine
- Rish Shah as Kamran Destine
- Laurence Fishburne as George Benny
- Emilia Clarke as Siriana Byll Jeeku
- William Hurt as Thaddeus Elliot Ross
- Olivia Colman as Juliette Somers
- Michael Douglas as Harry Pym
- Jade Xu as Helen Takahama
- Daniel Brühl as Helmutt Zemo
- Leslie Bibb as Christine Everhart
- Clark Gregg as Phillip "Phil" Jamie Coulson
- Samuel L. Jackson as Nicholas "Nick" Joseph Fury
- Aimee Teegarden as Dana D'Angelo
- Oakley Bull as Kobik
- Aaron Eckhart as Sentry
- Charlie Hunnam as Sentry
- Alexander Ludwig as Sentry
- Austin Abrams as Sentry
- Brad Pitt as Sentry
- Glenn Howerton as Sentry
- Henry Cavill as Sentry
- Alan Ritchson as Sentry
- Andrew Koji as Sentry
- Nikolaj Coster-Waldau as Sentry
- Alexander Skarsgård as Sentry
- Alexander Dreymon as Ka-Zar
- Colman Domingo as
- Mustafa Shakir as
- Anthony Ramos as
- Mallory Jansen as
- Imogen Poots as
- Daveed Diggs as
- Dafne Keen as
- Corey Stoll as
- Wilson Bethel as
- Clé Bennett as
- Bokeem Woodbine as
- Tom Hardy as
- Sam Rockwell as
- Peter Billingsley as
- Alison Brie will play Songbird, Jessica Drew's Spider-Woman, Sin, Mystique, Rogue, or Kitty Pryde
- Stephen Lang as Cable
- Martin Donovan as
- Milly Alcock as
- as Lester Jangles / Bullseye
- as MacDonald Gargan / Scorpion
- as Thomas Foster
- as Sybil Dvorak
- as Judith "Julia" Chambers / Satana
- as Brian Dunlap / Ogre
- as Jonathan Francis Walker / U.S. Agent
- as Norman Virgil Osborn
- as Barnard "Barney" McWilliams / Taskmaster
- as Rita DeMara / Yellowjacket
- as Parker Davis Robbins / Hood
- as Abigail Mercy Wright
- as Steven Mark Levins
- as Randall Spector
- as Abner Ronald Jenkins
- as Thomas Foster
- as Roberto Reyes
- as Samantha Sheridan
- as Ryan Topper
- as Captain Britain
- as Ares
- as Fixer
- as Mister Fantastic
- as Man-Thing